The Rath-Pauling therapy - A simple way to prevent / cure CVD related to atherosclerosis (Also used for rheumatoid arthritis, osteoarthritis and skin tone/elasticity)
The Rath-Pauling therapy is an inexpensive, nutrient-based, oral therapy to strengthen the body's connective tissue
Proposed by Dr. Matthias Rath and by the brilliant two-time Nobel prize winner, biochemist, physicist, molecular biologist – Dr. Linus Pauling
The therapy provides vitamin C and two amino acids to ensure production of sufficient collagen, to strengthen structural tissues throughout the body – notably for connective tissue in arterial walls, skin, muscle, nervoustissue, bones, cartilage, ligaments, tendons, and teeth. Collagen acts like a gluefor holding our cells together and is the body’s preferred substance for repairs.
The collagen fiber is like a 3-strand rope, consisting of amino acids L-glycine, L-proline and L-Lysine strands twisted around each other in helical fashion. An injury causes the collagen fiber to break, and just like a cut rope, frayed ends are left dangling. With sufficient vitamin C present, the frayed ends of L-Lysine, L-Proline and L-glycine are hydroxylated (chemically changed to L-hydroxyglycine, L-hydroxylysine and L-hydroxyproline ), which splices them back together.L-glycine is amply supplied in the body, but L-Lysine and L-Proline are not always available for repairing collagen.
A chronic (long-term) deficiency of vitamin C is essentially low-level scurvy.
So simple you may not believe it –Â Why is it that when a solution sounds too simple, we think that it could not possibly work? Instead, we are cleverly persuaded by the various arms of the medical system to put stock in their lucrative invasive medical procedures and expensive prescription drugs.
The Rath-Pauling therapy is used to fix health problems involving weakened structural tissue
Including:
-  Cardiovascular Disease (CVD) involving atherosclerosis  i.e. Ischemic CVD:  Includes coronary heart disease (CHD), arrhythmia, angina, carotid artery disease / stroke, hypertension, thrombosis (clot formation causing blockage) hemorrhagic burst (blood vessel rupture) and peripheral artery disease (PAD – can cut of circulation to arms / legs); The therapy also provides a faster recovery path for stroke victims.
Therapy solves two specific problems related to CVD involving atherosclerosis:
-  Its Lp(a) binding inhibitors (primarily the amino acids lysine and proline) prevent, resolve, and dissolve existing atherosclerotic plaque build-up – a fact supported by 3 U.S. patents.
- Its necessarily HIGH dose vitamin C activates lysine and proline and heals damaged arterial walls – smaller doses are less effective
- Rheumatoid arthritis
- Osteoarthritis
- Skin tone / elasticity – antiaging
Rath-Pauling Therapy to cure CVD
The following site provides more information on the Rath-Pauling therapy including testimonies and lectures by Dr. Linus Pauling himself.
Finding the cure for CVD - ♪ "How can you mend a broken heart?" ♪♫
In 1991, having determined that ischaemic CVD is simply a result of chronic, low-level scurvy (i.e. a vitamin C deficiency),Drs. Pauling and Rath published their groundbreaking paper:
“Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate Deficiency Leading to the Deposition of Lipoprotein(a) and Fibrinogen/Fibrin in the Vascular Wall”.
Next, they asked themselves the question of how life-saving plaques formed as a consequence of insufficient vitamin C  could be reversed. Your body intended the plaque to be a temporary repair patch over arterial damage to prevent you bleeding-out.
Plaques are made from a “sticky” variant of LDL cholesterol called lipoprotein(a) – the “a” stands for adhesive.
 Lp(a) – “The Cholesterol Repairman”
They found that Lp(a) cholesterol-binding sites are really just residues of collagen amino acids lysine and proline that become exposed when blood vessel walls “crack” (as in a lesion). These exposed residues attract the “sticky” Lp(a) molecules creating the plaque.
Pauling hypothesized that if there were sufficient vitamin C and more-than-normal amounts of lysine in the bloodstream, then the Lp(a) might be attracted away from the lesion and that normal collagen would take its place, restoring the artery wall to a healthy state and relieving the need for the repair plaque.
An associate of Pauling with a serious heart insufficiency tested the hypothesis – It worked! This associate had already been taking large doses of vitamin C, but was not getting any relief. Pauling suggested taking large amounts of supplemental lysine per day, and it worked. Within a few months he was able to function normally and there was strong evidence that his plaques were being reversed and the arteries healed. He increased the dosage and recovered completely. The same happened with other of Pauling’s associates, friends, and acquaintances.
Within a few years, hundreds of people had reported that their cardiovascular disease had been totally reversed.
According to the Rath / Pauling 1994 U.S. patent, a binding inhibitor (E.g. lysine or lysine analogs) together with vitamin C can stop and even reverse plaque formations – the amino acid lysine (lysine analogs), along with vitamin C and other antioxidants (E.g. Co-Q10, vitamin E and vitamin A) in sufficient concentration, can inhibit Lp(a) from binding to exposed lysine residues.
US Patent No. 5,278,189, Pauling/Rath (1994). Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
Another patent concerns stripping plaque from transplant organs (actually filed first) -in later experiments Pauling and Rath showed that proline residues are also exposed by lesions in blood vessels; they filed a U.S. patent for using proline as well as lysine, vitamin Cother amino acids and antioxidants (in oral amounts well past what is needed for prevention) to inhibit Lp(a) binding and so “melt away” atherosclerotic plaques in human organs dipped in these solvents during organ transplants
US Patent No. 5230996: Pauling/Rath (1993). A Procedure for the Cleansing / Removal of Atherosclerotic Plaque from Human Organs During Transplant Surgery.
A sufficient Vitamin C supply preferentially binds to and hydroxylates lysine and proline strands exposed in damaged artery walls and repairs the damage
Hydroxylation heals the damage by repairing collagen and also prevents these strands from “docking”onto Lp(a) receptor sites – with the result that some of the Lp(a) and plaque repairs leave the vessel walls, as confirmed by previous studies;
Rath and Pauling have two patents using their findings to remove plaque from arteries and also from organs during transplant surgery
Proline was found to improve the results by binding to additional Lp(a) receptors
Lp(a) is a combination of water-loving protein (apo a) and oil-loving cholesterol, and in contrast to L- Lysine, the unique amino acid L-Proline prefers oil to water (because of its five-member ring structure containing the amine portion of the molecule);
Pauling and Rath correctly hypothesized that proline would dock onto the oily receptor sites not covered by lysine – and astonishingly, adding proline to their solution completely cleared plaque blockages;
Therapy mechanism doesn't depend on the cause of plaque formation
It doesn’t matter if the arterial lesions were caused by mechanical stress, a vitamin deficiency, dietary oxidized cholesterol, elevated homocysteine or sugars, fat or toxis fats, or even . . . Little green men!
Cure means cure
End-stage CVD patients report an end to angina pain, color returns, blood pressure drops, blood flow increases, blockages disappear, heart rates drop, lipid profiles normalize, energy increases.  Patients can pass treadmill stress tests without surgery or any other medical intervention. Patients, previously struggling to walk, report that within months they can handle even strenuous work. Eventually, elevated Lp(a) levels are reduced.
The Therapy - Vitamin C, Lysine, Proline
Addresses the root cause of atherosclerosis in CVD by strengthening and gently healing blood vessels and removing plaque. While normalizing cholesterol and blood pressure.
- Vitamin C, Lysine, Proline are building blocks of collagen. Also, lysine promotes pituitary gland secretion of hGH (human growth hormone), the master hormone that will indirectly promote fibroblasts to produce more collagen throughout the body
- Vitamin C and Lysine inhibit the binding of Lp(a) molecules to the blood vessel walls – thus removing plaque build-ups.
- Sufficient lysine and proline work to unbind Lp(a) from the arterial wall – by blocking the collagen-digesting enzyme anchor sites in the connective tissue.
| Recommended ADULT DAILY Doses of Vitamin C, Lysine and Proline | |||
|---|---|---|---|
| Seriousness of Condition | Vitamin C | Lysine | Proline |
| Prophylactic/Prevention | 3 g | 3 g | 0.5 g |
| High risk Therapeutic | 6 g | 6 g | 1.0 g |
| Serious Therapeutic | 9 g | 9 g | 1.5 g |
The form of vitamin C recommended by Dr. Linus Pauling is pure pharmaceutical grade ascorbic acid:
- Not buffered.   Less is absorbed through the stomach wall
- Not combined as a mineral complexx(e.g. calcium ascorbate) – the high dosage levels of this therapy could result in an overdose of the complexed mineral..
Bowel Tolerance / Diarrhea. The onset of diarrhea indicates when the body’s true requirement of ascorbate (vitamin C) has been reached. Ascorbate is absorbed into the blood stream before it reaches the colon. When your bloodstream is full, it will not absorb anymore and ascorbate reaching the colon causes diarrhea.
Vitamin C is Better Taken in Smaller Separated Doses – About 80-90% of ingested ascorbic acid is absorbed into the blood from the small intestines. The body uses it in ~2 hours, and it has usually gone from the blood in 3-4 hours.
Take Vitamin C Consistently.   Once you start taking more vitamin C than usual, it is important to take it consistently, and to not stop, even for a day. If you want to reduce your consumption of vitamin C, do so gradually over a period of several days. Consuming high doses of vitamin C causes the body to create large quantities of enzymes that utilize the vitamin C. If vitamin C consumption is stopped suddenly, then these enzymes will go to work on the small quantity of vitamin C remaining in the body, with possible scurvy resulting.
Powdered Ascorbic Acid, Lysine and Proline – most ECONOMICAL form
- Add powders to a 6-8oz glass of water, juice or a “Green Drink” (a food-form vitamin/ mineral supplement). Powders have a mild taste and actually improve the tase of a green drink.
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| POWDERED INGREDIENTS | DAILY PREVENTATIVE DOSE | DAILY HIGH RISK THERAPEUTIC DOSE | DAILY SERIOUS THERAPEUTIC DOSE | |||
|---|---|---|---|---|---|---|
| Ascorbic Acid  (1g = 0.22 tsp.) | 3g | 2/3 tsp. | 6g | 1 1/3 tsp. | 9g | 2 tsp. |
| L-Lysine (1g = 0.57 tsp.) | 3g | 1 ¾ tsp. | 6g | 3 ½ tsp. | 9g | 5 tsp. |
| L-Proline (1g = ~ ½tsp.) or capsules (1 cap.=500mg) | 0.5g | ¼ tsp. (1 cap.) | 1g | ½ tsp. (2 caps.) | 1.5g | ¾ tsp. (3 caps.) |
Do not PRE-mix powders.  It casues the vitamin C to oxidize, turning the mixture pink.
| Dose Type | Vitamin C Powder | Lysine Powder | When | Proline 500 mg Caps | When |
|---|---|---|---|---|---|
| Prophylactic/Prevention | 1/3 tsp. | 7/8 tsp. | AM and PM | 1 capsule | AM |
| Better Maintenance Plan | Scant 1/4 tsp. | 1/2 tsp. | AM/ Noon / PM | 1 capsule | AM |
| High Risk Therapeutic | 1/2 tsp. | Generous 1 tsp. | AM / Noon /PM | 1 capsule | AM / PM |
| Serious Therapeutic | 1/2 tsp. | 1 ¼tsp | AM / Noon / 5PM / 9PM | 1 capsule | AM /Noon / PM |
How Long to Take Therapeutic Dose?    It is suggested that you take the therapeutic dose until you have confirmation that your health problem has been resolved – or you have some other reason for stopping.
What if you are currently taking statin or other drugs?
You, and only you, can decide how, when and if you should wean off any drugs you are taking.    The information provided on this website is intended to enlighten you to information, which hopefully will help you take responsibility for your own health.
Studies connecting Vitamin C deficiency with CVD
- Increased dietary cholesterol reduced vitamin C levels – and, conversely, vitamin C supplementation decreased cholesterol levels.
-  Willis found that Vitamin C reversed atherosclerosis in guinea pigs – like humans, they do not produce their own ascorbate
Willis GC. 1953. An Experimental Study of the Intimal Hemorrhages and in the Precipitation of Coronary Thrombi. Canadian Medical Association Journal, vol.69:pp.17-22.
Willis et al GC. 1954. Serial Arteriography in Atherosclerosis. Canadian Medical Association Journal, vol.71: pp.562-568.
Willis GC, Fishman S. 1955. Ascorbic Acid Content of Human Arterial Tissue. Canadian Medical Association Journal, vol.72:pp.500-503.
Willis GC. 1957. The Influence of Ascorbic Acid upon the Liver. Canadian Medical Association Journal, vol.76:pp.1044-1048.
Willis GC. 1957. The Reversibility of Atherosclerosis. Canadian Medical Association Journal of Nutrition, vol.77:pp.106-109.
1971 – British physician, Dr. Constance Spittle, demonstrated that vitamin C therapy could lower or raise cholesterol depending on presence of plaque- Patients exhibited a transitory rise in blood cholesterol when given vitamin C therapy -explained by cholesterol released from plaques as vitamin Chealed the blood vessel walls;
- Â Patients with no CVD showed lower blood cholesterol levels.
Spittle CR. 1971. Atherosclerosis and Vitamin C, The Lancet, Dec 11;(18):pp.1280-1.
Why is the Medical Profession not Utilizing the Rath/Pauling Therapy for Iscaemic CVD?
The medical profession and the National Institutes of Health (NIH) were not interested or impressed with the Rath/Pauling findings. The idea that cardiovascular disease was due to a simple nutritional deficiency and that a simple regimen of inexpensive nutrients and low-level exercise to get those nutrients to circulate, was very threatening to a medical system geared to and economically dependent on invasive medical procedures and expensive prescription drugs. Drug companies and for-profit hospitals have hundreds of billions of dollars at stake in investment and future revenues in conventional heart and vascular therapy. If they were to become common knowledge, the Rath/Pauling findings and therapy would eradicate cardiovascular disease in humans.
Twice the NIH flatly refused to fund studies of the regimen, citing extraneous “technicalities” for not proceeding. The National Academy of Sciences first accepted, then without reason canceled publication of Pauling and Rath’s definitive paper on the cause of cardiovascular disease, despite Pauling being an honored member of the Academy, one of the founders of modern chemistry and molecular biology, and the only recipient of two unshared Nobel Prizes.
The Pauling/Rath Unified Theory Paper (PDF) not published by the National Academy of Sciences:
http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf
Testimonies
Orthomolecular physicians have reported much success in treating heart disease with synergistic combinations of ascorbate, lysine and proline
Here’s just a couple of testimonies:
- Linus Pauling Case History:Â a National Science Medalist who had undergone several coronary artery bypass grafts (CABGs), each of which had re-clogged, and who had been prescribed statin drugs for high cholesterol as well as calcium channel blockers and beta-blockers for high blood pressure. After discussing his history with Pauling, this patient began a supplement program, including 6g of vitamin C; however, his condition continued to worsen. Pauling then suggested adding L-lysine (peaking at 6g/day) to his cocktail. The patient described the results as bordering on miraculous: his walking distance suddenly recovered, and he was again able to do his own yard work (including the cutting up of a tree with his chainsaw and the painting of his house).
- Dr. Kathie Dalessandri, MD: reported her own dramatic improvement in the Archives of Internal Medicine after using vitamin C and lysine. “I am a 53-year-old woman with a significantly elevated level of Lp(a) (27 mg/dL). . . I began to follow the advice of Linus Pauling. For individuals who have an Lp(a) level higher than 25 mg/dL and a family history of heart disease, the recommendation is to take 3 g/d of both ascorbic acid and L-lysine monohydrochloride.After 6 months of this regimen, with no adverse effects, my Lp(a) level decreased to 14 mg/dL, a reduction of 48%.”
